Principal Biostatistician

Location – Chicago, IL | Coralville, IA | or Remote-US

Digital Diagnostics is looking for a forward-thinking PhD-level Biostatistician with expertise in Artificial Intelligence (AI) and Machine Learning (ML) to join our dynamic team. This role bridges traditional statistical analysis with advanced modeling techniques to drive innovation across clinical trials, digital biomarkers, and real-world data (RWD) applications. The ideal candidate will bring deep statistical knowledge, hands-on experience with AI/ML methodologies, and the ability to apply these tools in the context of regulated clinical research and product development.

What You’ll Bring to the Team 

Required

• PhD in Biostatistics, Statistics, Computational Biology, Bioinformatics, or a related quantitative discipline
• 5+ years of experience applying biostatistical and machine learning methods to healthcare data in a clinical, academic, or industry setting
• Proficiency in statistical programming (e.g., R, SAS) and ML frameworks (e.g., Python, scikit-learn, TensorFlow, XGBoost, PyTorch)
• Demonstrated experience building and validating ML models for clinical prediction, image analysis, and digital health
• Familiarity with regulatory guidelines around AI/ML in healthcare, including FDA SaMD, Good -Machine Learning Practice (GMLP), and/or GDPR/ethical AI considerations
• Strong communication skills, with the ability to explain complex models to cross-functional teams and non-technical stakeholders
• Proven track record of peer-reviewed publications, conference presentations, or regulatory submission support

Preferred

• Experience with AI-driven medical devices, SaMD, or digital health products
• Familiarity with CDISC standards (SDTM, ADaM) and clinical trial data structures
• Exposure to real-world data (claims, EHR, registries) and techniques like causal inference or propensity modeling
• Participation in interdisciplinary AI/ML product development teams

What We Have to Offer 

• Supportive and flexible work environment 
• Remote-friendly culture 
• Access to competitive benefits 
• Mission-driven teammates who are working to tackle complex challenges to help improve the accessibility and quality of medical diagnosis
• Core behaviors that inspire day-to-day interactions
• Dedication to career growth and development of our team members through mentorship programs and defined growth paths 
• Virtual social and wellness events 

 Who We Are

Digital Diagnostics Inc. is a pioneering AI diagnostics company on a mission to transform the quality, accessibility, equity, and affordability of global healthcare. We pursue our mission through the application of technology in the medical diagnosis and treatment process. The company, originally founded by Michael Abramoff, MD, PhD, a neuroscientist, practicing fellowship-trained retina specialist, and computer engineer, is led in partnership with co-founders, John Bertrand, and Seth Rainford. Digital Diagnostics’ first FDA De Novo cleared autonomous AI system, LumineticsCore™ (formerly IDx-DR), is already improving patient outcomes by detecting diabetic retinopathy (including macular edema) at the point-of-care.

Digital Diagnostics is paving the way for autonomous AI diagnosis to become a new standard of care, contributing to democratizing healthcare and closing care gaps. The company works closely with patient advocacy groups, federal regulators, and other quality of care and ethics-focused stakeholders to enable adoption of autonomous AI. For more information and the latest news follow: https://digitaldiagnostics.com/

What We Believe 

At Digital Diagnostics, we’re doing “AI the right way” by building healthcare solutions that are safe, equitable, and accessible. We’re not only building a platform; we’re also building a community that emulates these values. We believe that inclusion and equity in healthcare start with a community of collaborators that celebrates human differences including race, ethnicity, gender, age, sexual orientation, human need, veteran status, political affiliation, and religion. We value what makes each person unique and create a place for everyone to thrive as we build towards shared goals. We’re committed to continuous learning and are striving to create a principled workplace while continuing to impact the world around us.

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This position can be located anywhere in the United States. We are not currently accepting applications for candidates located in countries outside of the U.S. Unfortunately, we are not able to sponsor an immigration case for employment at this time (for example, H-1B or other employment-based immigration cases).

No external agencies at this time, please.

Recently, there have been fraudulent employment offers sent to candidates on behalf of Digital Diagnostics. Please be advised that all legitimate offers will come directly from our official email domain (digitaldiagnostics.com) and will only be made after completing a formal interview process.

Here are some ways to check for authenticity:

• We do not conduct job interviews through non-standard text messaging or chat applications
• We will never request personal information such as banking details until after an official offer has been accepted and verified
• We will never request that you purchase equipment or other items when interviewing or onboarding

If you are unsure about the authenticity of an offer or if you receive any suspicious communication, please contact us at info@digitaldiagnostics.com.