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Senior Scientist, CMC - Drug Substance

Remote:

Full Remote

Contract:

Full time

Experience:

Senior (5-10 years)

Work from:

Massachusetts (USA), United States

Offer summary

Qualifications:

PhD in Chemistry/Biochemistry or MS with relevant experience, Background in synthetic chemistry and bioconjugates is a plus, Experience with solid-phase peptide synthesis is desirable, Familiarity with cGMP environments is a plus, Analytical skills in chromatography purification advantageous.

Key responsabilities:

Contribute to process development of peptides, oligonucleotides, and key raw materials
Develop optimized chromatography processes for purifying target entities
Manage drug substance logistics, including coordination of shipments
Work on CMC development projects with cross-functional teams
Support project planning and alignment with program goals

PepGen Scaleup https://pepgen.com/

51 - 200 Employees

See more PepGen offers

Job description

Senior Scientist, CMC - Drug Substance

Responsibilities

Contribute to the process development of peptides, oligonucleotides, conjugates, and key raw materials essential for PepGen’s platforms.
Collaborate with the discovery and analytical development team to develop optimized chromatography processes for purifying target entities.
Assist in managing drug substance logistics, including inventory control and coordinating domestic and international shipments of APIs and raw materials.
Participate in CMC development projects, working with stakeholders across Analytical, Quality, Preclinical, Toxicology, DMPK, and Pharmacology teams.
Support project planning, timelines, and objective setting within the drug substance group, aligning with CMC strategies and program goals.
Assist in drug substance development activities, including reviewing process development reports and testing results in collaboration with CMOs.

Requirements:

PhD in Chemistry/Biochemistry, or MS with relevant experience.
Background in synthetic chemistry and bioconjugates is a plus.
Experience with solid-phase peptide synthesis is desirable.
Familiarity with cGMP environments is a plus.
Analytical skills, particularly in chromatography purification, tangential flow filtration, and diafiltration, are advantageous.
Experience with scientific writing and documentation is a plus.

Note
This is not a remote role. We like to work together and operate in a hybrid model in office Tues, Weds & Thurs each week.

About PepGen
We are a biotechnology company advancing next-generation oligonucleotide therapies for neuromuscular diseases. Our ambition is to unlock the potential of nucleic acid therapeutics by leveraging the drug delivery capabilities of our proprietary Enhanced Delivery Oligonucleotide (EDO) platform. We are applying this technology across a wide range of indications and are rapidly growing our team at our U.S. headquarters in Boston, Massachusetts.

EEO Statement
PepGen is an Equal Opportunity Employer committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status.

Recruitment & Staffing Agencies: PepGen does not accept unsolicited agency resumes. Currently, we are working exclusively with The Bowdoin Group for all of our recruiting needs. Thank you.

The Scientist, Drug Substance will support the manufacturing and development of PepGen’s Enhanced Delivery Oligonucleotides (EDOs) pipeline. This role involves working closely with PepGen’s CMC team and external CMO/CRO partners to contribute to drug substance process development. The ideal candidate will bring innovative ideas and a collaborative spirit to a fast-paced, growth-oriented biotech company.