Senior Scientist, Immunotoxicology/Investigative Toxicology

Job Description

The Non-Clinical Drug Safety (NDS) organization within our company's Research Laboratories is currently seeking a senior scientist with immunotoxicology an background to join our Investigative Toxicology team at the West Point, PA site.

The senior scientist will be responsible for key aspects of immunotoxicology research and development, which includes but is not limited to understanding mechanisms of toxicity, supporting lead optimization, and developing novel assays and platforms for novel drug modalities. Further, the successful candidate is also expected to serve as a potential program toxicologist.

Key responsibilities include:

• Lead the design and implementation of fit-for-purpose in vitro and in vivo investigative tox plans to support immunotoxicity risk assessment and mechanistic investigations of new drug candidates.

• Responsible for the generation and reporting of immunophenotyping, antibody responses, and various immune or hematopoietic- cellular-based functional assessments. Accurately record data from experiments, including observations, measurements, and sample details, in electronic laboratory notebooks

• Troubleshoot technical issues, provide data interpretation, and prepare high quality immunotoxicity assay/study reports.

• Communicate effectively to Investigative Tox managers and stakeholders. Proactively identify gaps/risks in assay/study plans and inform the potential impact to team members.

• Provide scientific leadership and immunotoxicology subject matter expertise at multidisciplinary team meetings.

• Participate in external immunotoxicology consortia and symposia. Stay updated on the latest scientific research, regulatory guideline, and industry trends to guide informed decision and drive innovation in immunotoxicology safety assessment.

Qualification

• PhD in life science, such as Toxicology, Immunology, Biology, Biochemistry, Chemistry, or a related discipline.

• 0-3+ years of postdoctoral or industry experience in immunotoxicology or immunology areas.

• Hand-on experiences in immunoassays which can include flow cytometry, ELISPOT, TDAR, or other immune cell function/activity assessments (blastogenesis assay, NK cell function, cytokine release, etc.).

• Strong communication skills, with the ability to interact effectively with colleagues across multiple teams.

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