Job Description
Our Scientists are our Inventors. We deliver robust scientific data and interpretation that drives the commercialization of breakthrough therapeutics using innovative thinking, state-of-the-art facilities and modern equipment. Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of people like you. To this end, we strive to create an environment of mutual respect, encouragement and teamwork. As part of our global team, you’ll have the opportunity to collaborate with talented and dedicated colleagues while developing your career.
The Analytical Research and Development organization in Boston, MA is seeking a motivated Senior Scientist with technical expertise in solution state NMR for a role that primarily involves structure elucidation and investigation of small molecule drugs, peptides, and biologics. The successful candidate is expected to collaboratively work with synthetic, computational and analytical scientists, understand their problem statements, and collaboratively design and provide solutions, establish new NMR methods, and drive strategic innovation in the field of NMR. The candidate must be able to work proactively and independently and influence decisions and solutions spanning a wide diversity of problem statements across our company's Research Laboratories. The role will require the candidate to network across a range of departments and effectively collaborate with stakeholders. The role will requires positive ways of working which support diversity, inclusion, and a positive culture.
The ideal candidate is expected to be helping drive the field of NMR. This candidate will have an established track record of advancing scientific excellence through external presentations and publications. The role will involve mentorship of NMR colleagues. Additionally, the candidate will have advanced knowledge of analytical experimental design and the ability to provide technical leadership across all major pipeline modalities including small molecules, peptides, antibodies, proteins, ADCs, and vaccines. Finally, this Senior Scientist will be a partner in problem solving providing key leadership and driving collaboration both internally and externally.
Primary Responsibilities
Work performed in the NMR group includes structure elucidation, mechanism elucidation, reaction elucidation, analytical method development, physicochemical characterization, and quantitative NMR analysis.
Provide support for discovery research, discovery process chemistry, and analytical development, formulation, identification of process impurities, drug substance and product degradants, and characterization of other unknown molecules.
Meet with department members across functional teams to understand their scientific challenges. Propose and develop collaborative solutions with the NMR Sciences team that are aligned with prioritized focus areas. Help align AR&D strategic efforts to drive prospective impact.
Actively seek out, anticipate and solve diverse scientific, operational, and technical challenges.
Contribute to an evolving strategy across the NMR landscape.
Mentor junior scientists and create technical depth.
Demonstrate curiosity, multitasking, prioritization, and problem-solving skills in the planning, development, and execution of novel solutions to challenges.
Build external reputation individually and for the company.
Education Requirements
Required Experience and Skills
Strong knowledge of NMR including application in the pharmaceutical industry, establishing new NMR methods, and prospectively impacting problems related to drug discovery, characterization, and development
Strong knowledge of organic chemistry, biochemistry or physical chemistry
Experience performing structure elucidation in a medicinal or process chemistry environment
Comprehensive knowledge of NMR instrumentation, methodology and software
Skilled in the use and maintenance of Bruker or JEOL NMR software and hardware including cryoprobes and the application of NMR automation tools
Technically inclined with the ability to troubleshoot complex instrument problems (e.g., automation, robotic systems, cryogen fills, etc.)
Evidence of creative application of NMR techniques to problems of pharmaceutical interest
IT literate with the ability to manipulate data workflows in a networked environment (Windows and Linux OS, macros, scrips, etc.). Experience in scientific programming (Perl, Python) is desirable
Preferred Experience and Skills
Familiarity with multiple analytical methods for characterization of chemical matter across all drug modalities including, but not limited to small molecule, biologics, antibodies, proteins, enzymes, vaccines
Demonstrated leadership and supervisory experience related to training and mentoring junior scientists
Functional knowledge of computational chemistry or ability to apply molecular modeling methods to help solve NMR problems.
#EligibleforERP
NOTICE FOR INTERNAL APPLICANTS
In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.
If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.
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Employee Status:
Regular
Relocation:
Domestic/International
VISA Sponsorship:
Yes
Travel Requirements:
No Travel Required
Flexible Work Arrangements:
Not Applicable
Shift:
1st - Day
Valid Driving License:
No
Hazardous Material(s):
N/A
Job Posting End Date:
10/31/2024
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