Senior Director, Pathology

The Director of Pathology will report to Head of Translational Biology and be based in Columbus, OH. He/She will primarily serve as Study Pathologist for GLP Toxicology studies and as a peer-reviewer for external toxicology studies. This Pathologist will collaborate closely with the Head of Non-Clinical Safety and associated study directors. This position will also serve as Study Pathologist for in-house non-GLP studies to support the research and development of Sarepta’s portfolio. Additionally, he/she will work closely with the necropsy, histology, and morphometrics teams in supporting best practices for histopathology and digital pathology; including review of new staining techniques and image analysis algorithms, support for validation activities of fit-for-purpose digital image analysis methods and provide expert quality review of clinical and non-clinical histopathology images.

Primary Responsibilities Include:

• Serve as Study Pathologist in contributing to the design, macroscopic and microscopic examinations, interpretation, and reporting of GLP and non-GLP (exploratory, investigative, etc.) efficacy and toxicology studies conducted in-house and as needed, supervise necropsies.
• Serve as Peer-Review Pathologist on GLP and non-GLP toxicology studies conducted at CROs.
• Be a specialized resource for the histology and morphometrics team in developing and validating new staining techniques and digital image analysis algorithms
• Provide training, technical guidance and scientific leadership in necropsy and histopathology best practices to laboratory staff
• Serve as a resident subject matter expert in both in-house and outsourced investigative and toxicology studies and coordinate consultations with external experts in risk assessment of nonclinical pathology findings
• Evaluate and score in situ hybridization (e.g. RNAscope), IHC, IF, and special stains, as needed.

• Collaborate with other scientists on R&D-wide initiatives and research projects

• Additional pathology-related responsibilities as assigned

Desired Education and Skills: 

• DVM with DACVP certification or equivalent required; MS/PhD preferred
• Minimum of 3 years of experience in macroscopic and microscopic examinations of small and large animal tissues in toxicology studies and in the interpretation and investigation of the significance of pathology findings in an industry or academic setting
• Expertise/experience in the neuromuscular and CNS field highly desirable
• Knowledge and experience in digital pathology is highly desirable
• Excellent verbal and written presentation and inter-personal skills
• Strong scientific writing and problem-solving skills
• Knowledge/experience in clinical pathology preferred

#LI-TD1

This position requires work on site at one of Sarepta’s facilities in the United States.

Candidates must be authorized to work in the U.S.

Sarepta Therapeutics offers a competitive compensation and benefit package.

Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.